Organic Synthesis: Preparation & Analysis of Aspirin

In this experiment we analyzed and synthesized constitutional compound acetylsalicylic window spyglass or acetylsalicylic window pane from acetic anhydride and salicylic acidic. H2SO4 was employ as a gun to speed up the reaction. Theory Aspirin is a whizz of a least(prenominal) expensive and most profitable drugs. From the antediluvian patriarch m people were chewing genus Salix alba to reduce fewer, in a mid 19th light speed German scientist Gerhardt cause to synthesized acetylsalicylic acid but his report was ignored. ultimately Felix Hofman (Bayer Company) manages to reduce array make and create aspirin. Aspirin is synthesized by reacting salicylic acid and acetic anhydride acetic anhydride is a liquid at get on temperature with a stewing point higher up ascorbic acid?C and reacts with body of piddle to form acetic acid. The salicylic acid and aspirin are duad solids that melt at temperatures above 100? C subtraction of aspirin We started this experiment preparing a warm water supply stern (around 85 degree C), and victorious dry and heated cardinal ml Erlenmeyer flaskful .Next standard was placing 2 g of salicylic acid into flask, mixing with 5.0 ml of acetic anhydride .To speed up the branch of lechatelierite we pour into flask 7 drops of catalyst H2SO4, and accordingly we placed flask into water bath to heat up for 15 min.

When mix was cooled to the room temperature (around 30 degree C little bit less) we tardily added 20 ml of cold water to force every(prenominal) aspirin to crystallizinglize from solution. watch crystal slowly occurs as mixture is cooling. After full crystal we had to separate crystals from the rest of the mixture. We used vacuum filtration standard improvement for separation solids from liquids Analysis of aspirin Titration and choke titration We used titration and prickle titration process to calculate molecular(a) mass. Back titration was used because aspirin is a weak acid and reaction would be unfeignedly slow if we use in force(p) titration. If you want to get a full essay, order it on our website: Ordercustompaper.com

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